Avid Bioservices, Inc.
Protein Characterization and Purification


Avid Bioservices® offers a variety of mid-campaign characterization assays and product-dependent purification schemes. Concurrent assays may include growth curve generation, antibody concentration, endotoxin testing, viability and isotyping. There are a wide variety of post-manufacturing purification methods available. Proteins A and G are common affinity chromatography columns used as a first step in isolation, although more specific antigen columns can be custom linked to a support of choice. Other chromatography options for separation include size-exclusion and weak or strong ion-exchangers, some of which can serve additional purposes such as buffer exchange, concentration, polishing or viral reduction. Nano-filtration, detergent inactivation, low pH and increased temperature are yet other mechanisms available to customers for viral reduction and clearance. Purified antibodies can be forwarded to the customer in bulk solution, vials, or transferred to contracted formulation and filling facilities for further processing or lyophilization. GMP documentation is provided for manufacturing processes and GLP documentation can be provided upon request for test methods.

 



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